Uruguay has no injury concerns but could make changes to the side that beat Egypt 1-0. Winger Carlos Sanchez is tipped to start on the right, while the experienced Cristian Rodriguez could get the nod on the left wing after Giorgian De Arrascaeta failed to impress.
Saudi Arabia head coach Juan Antonio Pizzi could drop a number of players, with goalkeeper Abdullah Al Mayouf likely to replace Mohammed Al Owais.
Elsewhere, he may be tempted to start with Muhannad Assiri in the lone forward role in place of the ineffective Mohammed Al Sahlawi.
Saudi Arabia and Uruguay have never met at the World Cup. However, the Green Falcons are undefeated in their two previous games with Uruguay (W1, D1), both home friendlies.
Uruguay could win their opening two matches of a World Cup for the first time since 1954.
They have lost just one of their last nine World Cup group games (W5, D3), winning five of their last six.
The Uruguayans have also won all three of their previous World Cup games against Asian opponents, scoring five and conceding just once.
The last time they won their opening group game, a 2-0 victory over Israel in 1970, they went on to reach the semi-finals.
Luis Suarez is set to win his 100th cap in this game. He’ll be the sixth Uruguayan to reach that milestone.
Uruguay16:00 Saudi Arabia
Portugal 13:00 Morocco
Iran 19:00 Spain